Imaging regulation of endogenous gene expression using spliceosome-mediated trans-splicing.

Recent years have witnessed a remarkable increase in our knowledge and understanding of the genetics and molecular biology of human diseases. During the past 2 decades, technologic innovations revolutionized molecular and cell biology. Significant progress in the understanding of the molecular– genetic mechanisms of many diseases has been achieved with the advent of the modern molecular–biologic assays. The development of transgenic animal models of human diseases, which allow the molecular basis of the disease to be studied in a living organism, has provided